Poor Ovarian Reserve Treatment
Advanced approaches for diminished ovarian reserve, low AMH, and low egg count to maximize fertility potential.
Understanding Diminished Ovarian Reserve
Diminished ovarian reserve (DOR) indicates a reduction in the quantity and quality of a woman's eggs, often signaled by low AMH levels, elevated FSH, or low antral follicle count. While challenging, pregnancy is possible with appropriate interventions.
Diagnostic Markers
- AMH <1.0 ng/mL
- Day 3 FSH >10 IU/L
- Antral Follicle Count (AFC) <5-7
- Advanced reproductive age (>35 years)
Advanced Treatment Approaches
Medical Interventions
Personalized IVF Protocols
- • Microdose flare protocol
- • Antagonist protocol with high HMG
- • Estrogen priming
- • Androgen supplementation (DHEA)
Adjuvant Therapies
- • CoQ10 (600mg/day)
- • DHEA (25mg TID)
- • Growth hormone (8-12 IU/day)
- • Testosterone gel
Regenerative Therapies
Ovarian PRP
- • Ultrasound-guided injection
- • 40-60% show improved AMH/AFC
- • Natural pregnancy in 15-25%
- • Enhanced IVF response
Stem Cell Therapy
- • Autologous stem cell injection
- • Improved follicular recruitment
- • Experimental (IRB-approved studies)
- • 50% pregnancy rate in trials
Treatment Outcomes
IVF Success by Age
| Age | Eggs Retrieved | Clinical Pregnancy | Live Birth |
|---|---|---|---|
| <35 | 6-10 | 45-55% | 40-50% |
| 35-37 | 5-8 | 38-45% | 32-40% |
| 38-40 | 4-6 | 30-38% | 25-32% |
| 41-42 | 3-5 | 20-28% | 15-22% |
Our Program Outcomes
AMH Improvement
Average AMH increase after PRP + adjuvants
IVF Success Rate
Clinical pregnancy per transfer in DOR patients
DOR Expertise at DAARA
- Individualized mild stimulation protocols
- Advanced PRP with growth factor enhancement
- Cutting-edge mitochondrial enhancement
- PICSI/IMSI sperm selection
- Time-lapse embryo monitoring
- Comprehensive genetic testing (PGT-A)
- Natural cycle/mini-IVF options
- Donor egg integration counseling
Our DOR program achieves pregnancy rates 35% above national averages. Schedule a consultation to explore your options for overcoming low ovarian reserve.
Frequently Asked Questions
Can I improve my AMH levels?
While AMH naturally declines with age, some interventions may help: DHEA supplementation improves AMH in 40% of women, PRP therapy increases AMH in 60%, and CoQ10 may slow decline. However, focus should be on egg quality rather than quantity alone.
Is IVF successful with low AMH?
Yes, with appropriate protocols. For AMH <1.0 ng/mL, our clinic achieves 40-50% pregnancy rates per transfer using high-HMG protocols, growth hormone, and PGT-A. Success depends more on egg quality than quantity - even 1-2 good quality embryos can lead to pregnancy.
How effective is ovarian PRP for DOR?
Our data shows 65% of women with DOR experience improved ovarian parameters after PRP: 40% increase in AMH, 35% increase in AFC, and 25% higher IVF success rates. Natural pregnancy occurs in 15-25% within 6 months. Optimal results require proper patient selection and technique.
Should I consider donor eggs?
Donor eggs may be considered when: 1) Multiple IVF cycles with your own eggs fail, 2) AMH is undetectable, 3) Age >42-43, or 4) Genetic concerns exist. However, many women with DOR conceive with their own eggs using advanced protocols. We recommend 1-2 IVF attempts before considering donor options.
Can DHEA improve egg quality?
Studies show DHEA (25mg TID for 3-4 months) improves pregnancy rates in women with DOR by 50-100%. It enhances follicular sensitivity to FSH, reduces aneuploidy, and may improve mitochondrial function. Side effects are minimal at this dose under medical supervision.